Oxidative stress occurs when the levels of free radicals and antioxidants in the body is not balanced. Free radicals can be formed as a result of an increase in blood glucose levels in Diabetes Mellitus that can cause damage to cells, tissues, and organs such as the liver, kidneys, heart. Antioxidants are necessary to dampen the negative effects of oxidants. Flavonoids on the cherry crop is antioxidative. This research is experimental research design with post test with only control group design. The subjects were white rats Sprague dawley many as 36 tails were divided into 6 groups: group 1 (normal), group 2 (negative control), group 3 (positive control), group 4 (steeping leaves of cherry 250 mg/200 grBW), a group of 5 (cherry leaves steeping 500 mg/200 grBW), and group 6 (cherry leaves steeping 750 mg/200 grBW). 2-6 group induced with streptozotocin dose of 65 mg/KgBW and nicotinamide 230 mg/KgBW for 5 days until the rats became Diabetes Mellitus (fasting blood sugar >135mg / dl) were then given treatment for 14 days. Intake levels of GDP using enzymatic method GOD-PAP, while SOD using Kit BioVision. Data were analyzed using paired t test and One Way Anova. The results of statistical tests with paired t test showed significant differences in the levels of GDP before and after treatment (p = 0.0001). In One Way Anova mean SOD are different in each group (p = 0.0001). The most effective steeping increase SOD is the dose of 750 mg/200 grBW.