Hypertension was defined as systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg. Prolonged hypertension may affect depression or the reciprocal relation between depression that cause hypertension. Depression is a mood disturbance with prevalence in hypertension’s patient about 20-30%, this may be due to biological factor, genetic factor and psychosocial factor, but it is also because of demographic factor, such as gender, age group, education level, occupation and marital status. These factors can influence each other. Therefore, research on the relationship between demographic factor with depression in hypertension’s patient in Gunungkidul DIY is very important to do. Method: This study is a non-experimental with cross sectional approach. As 36 hypertension patients are measured the depression score using a Beck Depression Inventory (BDI) questionnaire. Purposive sampling technique is used so that we got 36 patient as samples. Then the data will be analyzed using chi-square test. Result: From 36 samples in this study, it was found that hypertension’s patients had 63,9% normal or minimal depression, 13,9% had mild depression, 16,7% had moderate depression and 5,6% had severe depression. The results of chi-square test showed that demographic factors (gender; age group; education level; occupation and marital status) is not associated with depression, with p value= 0,880; 0,404; 0,331; 0,983 and 0,733 (not significant), where p> 0,05. Conclusion: In this study, there is no significant relationship between demographic factor with depression in hypertension’s patient in Gunungkidul DIY.