Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both that can cause a variety of macrovascular and microvascular complications. The microvascular complications are neuropathy, nephropathy, retinopathy and gangrene. Diabetic neuropathy is one of themosct common chronic microvascular complications found in people with diabetes mellitus. Complications arise due to various factors such as dyslipidemia, low blood sugar control, long duration of diabetes mellitus, hypertension and other risk factors. In this study, lipid profiles studied were triglyceride levels. Methods: This study was a quantitative research with observational research design and analytic cross sectional approach. Samples of this study in which patients with diabetes mellitus in RSUD Kota Yogyakarta of 60 respondents drawn at random.Analysis of the data usechi-square test 2x2 to see the relationship between these two variables. The research instrument used in this study is the medical record and score Diabetic Neuropathy Symptoms (DNS). Result and Discussion :The result showed 33 patients (55%) had complications of diabetic neuropathy and 27 (45%) patients were not diabetic neuropathy. The result of this studyshowed no significant association ofhypertriglyceridein diabetic patients with the incidence of diabetic neuropathy, with p = 0.592 and odds ratio (OR) = 1.408. Conclusion:This research concluded that there is no relationship between hypertriglyceride with the incidence of diabetic neuropathy.