Diabetes Mellitus complication is influenced by duration and succesfull of DM control. Uncontrolled DM patient have 2 - 3 times risk of infection. Metabolic disorders result to neuropathy and ischemia in the legs and feet. This may lead to a diabetic ulcers which are the most common complication. According to Wagner diabetic ulcers are classified into five categories. Neuropathy diabetic may be examined by DNE (Diabetic Neuropathy Examination) and DNS (Diabetic Neuropaty Score). The optimal therapy of diabetic ulcers were undetermined, because of the bacteria involved and the efficacy of antibiotics therapy remains unclear. The aims of the study is to determine the pattern of antibiotic sussceptibility and the role of antibiotic therapy in the management of diabetic ulcers. Prospective cohort study, crosssectional experimental laboratory design and pre-test - post test randomized control group design. There are 38 subjects involved, 26%o men and 74Yo women. No significant differences in terms of age, initial GDS, the DM duration, the ulcers duration, ulcer recurrence rate and baseline score of DNS, DNE and wagner. The proportion of antibiotics which were prescribed including Clinda- 90 mycin, Cefadroxil, Ceftriaxon, Amoxicillin Ciprofloxacin and cefotaxime were 13.2%, 5.3o/", 28.9%, 18-4%, 23.7% and 10'5% respectively' Antibiotics therapy did not significantly influence the effectiveness of treatment acording to the DNS, DNE and Wagner. The relative risk of each antibiotic therapy were computed and results showed: Clindamycin (RR = 2.571) and Cefotaxim (RR = 2.306) based on DNE scores; Clindamycin (RR = 2-29L) and Ciprofloxacin (RR = 2'880) based on Wagner. The RR above 2 can be considered as clinically effective. Cyprofloxacin is the most sensitive antibiotics, followed by Clindamycin and Cefadroxyl as much as 60'5% and 57'8% respectively' Six antibiotics did not significantly effective for diabetic ulcers therapy based on DNS, DNE and Wagner. Clindamycin, Ciprofloxacin and Cefotaxim might be considered clinically effective'