Circumcision is a minor surgery for Childs that mostly done around the world. Circumcision have aims for deleting the preputium area and cleaning up the of waste product (smegma) for the reason due to completely do a praying (moslem) and other reasons like social, culture, and health. Good Pain management is really help to do circumcision. Paracetamole is a drug from acetaminophen categories, could inhibit the production of prostaglandin in peripheral tissue and it is not significantly has inflammation effect, then it could use for pain management in circumcision. Paracetamol is is a drug from acetaminophen categories, could inhibit the production of prostaglandin in peripheral tissue and it is not significantly has inflammation effect, then it coud us for pain management in circumcision. Ibuprofen is a anti inflammantory non streroid (AINS), it works by reduce prostaglandin biosynthesis that causes inflammation and pain in the body. This research was performed by using quasi experimental aims to know affectivity of given paracetamol before and ibuprofen after circumcision. The subjects of this research were 38 children, divided into two treatment groups who perform circumcision using techniques dorsumsisi on a “Khitanan Massal” held in RSKIA Sadewa, Sleman, Yogyakarta. The Independent Sample Test analysis show that the score Sig. (2-Tailed) is 0.005 (p-value < 0.05), therefore there is significantly the deifferences between paracetamol pre and ibuprofen post. It can be conclude that Ibuprofen post circumcision is more effective as an analgesic effect than paracetamol pre circumcision.