Background : Occupational health and safety in the hospital environment are still low and have not become a priority for hospitals. Health workers are workers who are at risk of occupational illness and occupational accidents in hospitals, one of them in the field of radiology. The SOP in the radiology department is a preventive measure against the side effects of radiation use. The purpose of this study : To determine the effect of knowledge and attitudes of radiology officers on compliance with radiological occupational health and safety SOPs. Methods : The research used in this study is quantitative descriptive. The populations in this study were 13 people. Non-probability sampling is done through saturated sampling. Data analysis of this study was carried out through the Pearson Product Moment correlation test and multiple correlations. Results and Discussion : The significance value of knowledge on compliance with the application of SOP is 0.030 (sig <0.05), the correlation is 0.616, the significance of attitudes toward compliance with the application of SOP is 0.011 (sig <0.05), and the correlation is 0.746. The significance value of knowledge and attitudes towards compliance with the application of SOP is 0.046. This shows that there is an influence between the knowledge and attitudes of radiology officers on SOP compliance.