In 2016 approximately 3,143 regional regulations were revoked. Ministry of Law and Human Right through its regional office which functions to facilitate the design of regional legal products has the responsibility for revoking the regional regulations. Due to this task, the study on the regulation making process as well as its obstacles during the process should be undertaken. By using a normative-empirical method and descriptive-qualitative approach, this research aims to understand how the regional making process and its obstacles faced by Regional Office of the Ministry of Law and Human Rights, Special Region of Yogyakarta. The findings indicate that the process of making regulation has been conducted in accordance with its duties and functions as stated in the standard operational given by the Ministry of Law and Human Rights also several obstacles have hindered the process such as sectoral political ego of government, the passive relationship between regional office and government, lack of socialization, and lack of professional organization functions of legislative designers. It is recommended to encourage the government awareness on its function and authority, conduct intensive socialization of Regional Office roles, formulate regulation that consists of detailed mechanisms on relations between regional office and government; and reactivating the long-vacuum legislation designer professional organization.