Global Tuberculosis Control WHO Report 2013 declared that Indonesia is the 3rd largest contributor of Tuberculosis (TB) in the world after India and China with mortality rate 27/ 100,000. TB patient who rarely consume OAT can cause low cure rates, high mortality rate and increase risk of reccurence. Knowledge about TB is crucial to give awareness to patients on the importance of taking medication regularly. The aim of this study is to determine the correlation between knowledge of Pulmonary Tuberculosis with adherence to take OAT in patient with pulmonary tuberculosis in Sidawangi hospital, Cirebon, West Java. This study is a non-experimental with analytical correlation and cross sectional approach. Sampling was done by using purposive sampling on June-July 2015 in Sidawangi Lung Hospital, Cirebon, West Java with a result of 42 respondents available on that period. The level of knowledge and patient adherence was measured by questionnaire for level of knowledge, and Morysky Medication adherence Scale (MMAS-8). The correlation between level of knowledge and adherence was analyzed by Pearson Product Moment Correlation test with a significance level of 95%. The result showed that the respondents with high level of knowledge was 83.30%, 14.30% with medium level of knowledge and 2.40% with low level of knowledge. The high level of adherence to consume Anti Tuberculosis drugs was shown in 78,60% respondents, the medium level of adherence was shown in 14,30% respondents and the low level of adherence in 7,10% respondents. Analysis of the correlation between level of knowledge and adherence level showed a p value of 0.000 (<0.05) with correlation value (r) = 1.000. It can be concluded that most of TB patients in Sidawangi Lung Hospital, Cirebon, West Java had high level of knowledge and adherence. There was a very strong correlation between level of knowledge and the adherence level of the patients.