Shortage of professional nurse in a hospital is threatened service quality and patient safety. Inadequate compensation, no career development, and dissatisfaction can increase turnover intention. Increasing the resilience of professional nurses better than recruiting new nurses from an economic perspective. The research analyzed the effect of compensation and carrier development on job satisfaction and the impact on turnover intention of nurses in a private hospital in Yogyakarta, Indonesia. A quantitative research design with a cross-sectional approach used. The sampling technique was a simple random sampling. The samples consist of 47 nurses who made a self-reported by filling out the questionnaire. Data analysis used Partial Least Square. The study found that compensation and career development had direct and significant effects on Turnover Intention. Moreover, compensation and career development also had indirect and significant effects on Turnover Intention through job satisfaction as the intervening variable.