Pharmaceutical care is cannot be separated from caring system in a hospital which oriented on patient care. Nowadays, Pharmaceutical care had been changed from drug oriented become patient oriented. The pharmaceutical care is intended on clinic pharmacy. The purpose of this study is finding out whether the pharmaceutical care especially clinic pharmacy has been appropriate with the standard of Permenkes RI NO.58 tahun 2014 and finding out the significant difference between hospital level and total number of the pharmacist with the implementation of clinic pharmacy service in the hospital. The kind of this study is analytical research with cross sectional approach. In analyzing the data the writer used descriptive-correlative method. This study was done at some hospitals; PKU Muhammadiyah Yogyakarta, PKU Muhammadiyah Gamping, PKU Muhammadiyah Bantul dan PKU Muhammadiyah Nanggulan. The data was collected by interviewing and giving questionnaires to the pharmacist at Rumah Sakit Amal Usaha Milik Muhammadiyah in Yogyakarta. The study indicated that mean score of clinic pharmacy at Rumah Sakit Amal Usaha Milik Muhammadiyah in Yogyakarta was 74,5%. The services are mostly done are inspection and prescription service, investigation of medicine using history, counseling and medicine information service. Meanwhile result of correlation test towards the influence of hospital level was r = 0,465 and r =0,307 for the influence of the total number of pharmacist. It means there is no significant correlation between hospital level and total number of pharmacist with the implementation of clinic pharmacy service in the hospital. In conclusion, the service of clinic pharmacy in the hospital has been appropriate with the standard of Permenkes RI NO. 58 tahun 2014, but the level of hospital and total number of pharmacist did not influence towards clinic pharmacy service in the hospital.