This study aims to analyze the impact of macroeconomics variable on Islamic banking profitability in Indonesia which is measured by Return On Assets (ROA). The variables of macroeconomic in this study include inflation, exchange rate, and gross domestic product. This research used secondary monthly data from 2012-2015, and analyze using multiple regression model. The research findings was indicate, through 3 independent variables used, there were 1 variables that significantly influence to performance of Islamic bank. That is exchange rate. While the variable of inflation and gross domestic product was not significantly influence to the performance of Islamic bank.