Background: Diabetes Mellitus (DM) is one of the major threats for human health in the 21st century. The impact of DM disease will lead to a serious complication. One of the most common diabetes mellitus complications is diabetic ulcers. In line with the increasing prevalence of DM patients, the incidence of diabetic ulcers is increasing. Increased levels of platelets clinically often occur in diabetics with a long duration of the disease. High platelet levels and the presence of platelet dysfunction can be dangerous for microcirculation and increased risk for vascular complications, including diabetic ulcers. This study is needed to determine the difference in platelet levels in people with type 2 DM with diabetic ulcers and without diabetic ulcers. Methods: Cross-sectional study. was conducted by taking data of platelet levels from medical record of type 2 DM with and without the complication of diabetic ulcer that fulfilled inclusion criteria. The study was conducted in the hospital of PKU Muhammadiyah Yogyakarta in May - June 2017. The total sample used was 32 samples of type 2 diabetes mellitus consisting of 16 group samples with diabetic ulcers and 16 group samples without diabetic ulcers. Further data were analyzed with Independent Samples Test. Result: The mean value of platelet levels in the group with an ulcer, ie 319,62 103 / μL and in the group without ulcer, ie 275,81 103 / μL so that the average value of platelet levels in the group with ulcers higher than the group without ulcers. There were significant differences in platelet levels between groups with ulcers and non-ulcer groups. This can be proven from the result of p <0,05 (p = 0,032) by using Independent Samples Test. Conclusion: From this study, it can be concluded that there are differences in platelet levels between people with type 2 DM with diabetic ulcers and type 2 DM patients without diabetic ulcers.