Background: Triglyseride is one of the types of fat existing in blood and other parts of the body. According to the science of chemistry itself, triglyseride is a substance consisting of glyserol that ties saturated and unsaturated fatty acid. Papaya is a fruit that originally comes from south Mexico. Papaya seeds have hypolepidemia and antioxidant effect. Turmeric is one type of plant spices and traditional medicine grown in Southeast Asia. From the previous mouse research which was given curcumin orally, there was no damaging effect observed from its faeses n urine. Research Method: This is an experimental research with a pretest posttest control group design. There were 25 white mice (Ratus nivergitus) as the research subjects, consisting of 5 groups, those were, group 1 (negative control), group 2 (positive control), group 3 ( combination of papaya seeds juice 100 mg/kgBW/day and turmeric juice 70mg/kgBW/day), group 4 (combination of papaya seeds juice 200mg/kgBW/day and turmeric juice 70mg/kgBW/day) and group 5 (combination of papaya seeds juice 400mg/kgBW/day). Each group had 5 mice. The same treatment were given to each group for 21 days. The level of triglyseride was measured by colorimetric enzymatic GPO. Research outcome: The result of the data analysis paired samples t-test for each group before and after K+ treatment are as follow, Test 2 resulted P>0,05 and on Test K-, Test 3 resulted P<0,05. On One Way Anova Test on each group before and after treatment K+, Test 2 resulted P> 0,05 and on Test K-, Test 1, Test 3 resulted P< 0,05. Conclusion: By combining papaya seeds and turmeric juice as long as 21 days can reduce triglyseride level on white mice Rattus Norvegitus that have experienced hypercholesterol.