Background: Cardiovascular is the fisrt number as cause of morbidity and mortality around the world. The main risk factor of cardiovascular is dislipidemia, a condition where the total cholesterol consentration increased, LDL, triglyceride and the decreasing concentration of HDL from the normal condition. The most accurate parameter in predicting about cardiovascular is the comparison of LDL and HDL cholesterol value called cholesterol ratio LDL:HDL. The aim of this research is to know if the combination of papaya seed juice and turmeric juice is able to decrease the cholesterol ratio LDL:HDL of a white mouse which has been inducted by dislipidemia. Research Method: The research is an experimental research with pretest posttest control group design. The research subject is 25 white mice (Rattus norvegitus) contained of five groups, first group is negative control, second group is positive control, third group is the combination of papaya seed juice 100mg/kgBB and turmeric juice 70mg/kgBB, fourth group is the combination of papaya seed juice 200mg/kgBB and turmeric juice 70mg/kgBB and the fifth group is the combination of papaya seed juice 400mg/kgBB and turmeric juice 70mg/kgBB and each group consists of 5 mice. The treatment is given for 21 days each. Result Outcome: The combination of A Papaya seed juice (dose of 100mg, 200mg, and 400mg) and A Turmeric juice (dose of 70mg) has able to lowered the LDL:HDL cholesterol rate significantly (P<0,05). There are significant differences between the treatment groups (P<0,05). Conclusion: Giving the combination of papaya seed juice and turmeric juice to the white mice Rattus norvegitus which has been inducted by dislipidemia is able to decrease the cholesterol ratio LDL:HDL.