Background: One push contains toxic substance that is excessively dangerous which is transfultrin 21,3%. Spray contains toxic substance that is not excessively dangerous which is praletrhin (0,1%), siflutrin (0,05%), and d-allethrin (0,57%). Renal is an excretion organ for substance that is not necessary for the body. This study aims to know the influence of one push and spray toward renal’s histology image and to know the difference of those influence. Method: This study’s design is laboratoric experimental with posttest only control group design. This study is conducted toward 30 Rattus norvegicus that are divided into 5 groups. The first group is given exposure for 60 days. The data is taken and glomerulus’s diameter and the size of bowman space are counted to know the damage of renal. Result: The result of this study is analyzed using One Way Anova test. The result of this study shows that there is no significant difference of the glomerulus diameter among all groups with p value >0,05, whereas the size of bowman space among all groups show p value <0,05 which means there is significant difference of the size of bowman’s space diameter. Conclusion: There is a difference between the influence of one push insect repellent’s exposure and spray insect repellent toward renal damage.