| dc.contributor.advisor | | |
| dc.contributor.author | HANIFAH, NADA DIINUL | |
| dc.date.accessioned | 2018-04-17T04:24:56Z | |
| dc.date.available | 2018-04-17T04:24:56Z | |
| dc.date.issued | 2017-06-10 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/18514 | |
| dc.description | Obat nyamuk merupakan obat yang digunakan untuk membasmi nyamuk.
Saat ini jenisnya sangat beragam. Misalnya one push mengandung zat toksik
berbahaya yaitu transfultrin 21,3% dan spray mengandung zat toksik berbahaya
yaitu praletrin (0,1%), sifultrin (0,05%), dan d-aletrin (0,57%). Hepar adalah
organ yang berfungsi sebagai pertahanan tubuh dan detoksifikasi racun. Penelitian
bertujuan untuk mengetahui pengaruh one push dan spray terhadap gambaran
histologi hepar serta mengetahui adanya perbedaan pengaruh.
Jenis penelitian ini adalah eksperimental murni dengan post-test only
control group design. Subyek penelitian 30 ekor (Rattus norvegicus) usia 2 bulan,
dibagi 5 kelompok yaitu kelompok kontrol (K), kelompok one push 5 menit (P1),
kelompok one push 10 menit (P2), kelompok spray 5 menit (P3), dan kelompok
spray 10 menit (P4). Perlakuan dilakukan dilakukan selama 60 hari. Hari ke 61
tikus dibedah untuk diambil heparnya, kemudian dibuat preparat histologi. Data
diambil dan dinilai skor kerusakkan sel hepar dengan skoring kerusakan hepatosit
kriteria Manja Roenigk.
Analisis Kruskal-Walis menunjukkan hasil rata-rata kerusakkan sel hepar
kelompok K(277,37±7,485); P1(306,07±16,366); P2(307,68±31,125);
P3(297,20±12,629); P4(314,18±27,354) dengan p=0.515 (tidak signifikan). Dapat
disimpulkan bahwa obat nyamuk one push dan obat nyamuk spray berpengaruh
terhadap perubahan histologi sel hepar Rattus norvegicus dengan perbedaan yang
tidak signifikan. | en_US |
| dc.description.abstract | Musquito repellent drugs is a drugs that used to eradicate mosquitoes. In
this time, there are so many anti-mosquito drugs. One of the example is one push
that contain dangerous toxic which is transfultrin 21,3% and spray contains a
toxic dangerous praletrin (0.1%), silfutrin (0,05%) and d-aletrin (0,57%). Hepar
is an organ that have function as a body imunity and poison detoxification. This
research’s purpose is to know the one push and spray effect to the histological
image of the hepar and to know is there any influental differentiation.
This researh’s type is pure experimental with post-test only control group
design. The subject in this research is 30 (Rattus norvegicus) with 2 months age,
divided into 5 group which is control group (K), 5 minutes one push group (P1),
10 minutes one push group (P2), 5 minutes spray group (P3), and 10 minutes
spray group (P4). The experiment is 60 days. In the 61th day we operated the rat
to get the hepar and then we make the histological preparate. We get the data and
we assess the hepar cell damaged score with the hepatosit damaged score in
Manja Roenigk criteria.
The experimental results were analyzed using Kruskal-Wallis test. The
results groups of K(277,37±7,485); P1(306,07±16,366); P2(307,68±31,125);
P3(297,20±12,629); P4(314,18±27,354) with p=0.515 (not significant).
Conclusion that one push and spray effect on histologic changes of hepatic cell of
Rattus norvegicus with difference is not significant. | en_US |
| dc.publisher | FKIK UMY | en_US |
| dc.subject | Liver, spray, one push. Hepar, spray, one push. | en_US |
| dc.title | PENGARUH OBAT NYAMUK SPRAY DAN OBAT NYAMUK ONE PUSH TERHADAP GAMBARAN HISTOLOGI HEPAR (Rattus norvegicus) | en_US |
| dc.type | Thesis
SKR
FKIK
473 | en_US |
