This study is aims to analyze the influence of Gross Regional Domestic Product (GRDP), Foreign Direct Investment (FDI), Domestic Investment (DI), education and unemployment against human development index (HDI) in the Indonesia period 2010-2016. This research used quantitative using secondary data and panel data be taken according by thirty provinces in Indonesia. The analysis methods was used in this research are using panel data analysis methods with random effect model (REM). The results of the panel data model analysis showed that the independent variable Gross Regional Domestic Product (GRDP), Foreign Direct Investment (FDI), Domestic Investment (DI) and education positive and significant effect to human development index (HDI). While variable unemployment negative and significant effect to human development index (HDI) in the Indonesia period 2010-2016.