In this global era, health practitioners have demands to give quality health services. Quality service can be obtained from good collaboration among the health practitioners. One of the attempts to realize the effective collaboration inter profession is the need of early collaboration practice through learning process. It is by training the students of health education to use the strategy of Interprofessional Education (IPE). The objective of the research was to find out the different perception and attitude of cooperation among the students with and without IPE exposure. The method of the research was quantitative in nature with descriptive analytical design and used cross sectional approach. The measurement of the perception towards IPE was measured by using Interdiciplinary Education Perception Scale (IEPS), while the attitude of cooperation was measured by using Attitudes towards Health Care Teams Scale. The research was conducted in March 2017. The respondents consisted of 72 respondents with exposure and 150 without exposure IPE. The result of the perception measurement showed that 76.39% respondents with IPE exposure had a good perception about IPE and the respondents without IPE exposure had value of 67.33% with category of good. The measurement result of attitude of cooperation showed that 83.33% respondents with IPE exposure had the attitude of cooperation with category of good and the respondents without IPE exposure had value of 70% with good category. With perception significance value of 0.039 and the attitude of cooperation significance value of 0.025 (p<0.05), it could be concluded that there was a significant difference towards IPE and the attitude of cooperation among the respondents with and without IPE exposure. This proved that with the IPE learning process, it would make the students have better perception and attitude of cooperation.