Diabetes mellitus is a chronic metabolic disease, characterized by a disturbance in metabolism as a result of insulin secretion decreased, or due to decreased insulin sensitivity of the cell body cells. Diabetes mellitus can worsen with depression. SEFT is one of the complementary therapies that can be used to reduce depression levels, so it is hoped that after SEFT therapy in patients can help to improve the quality of life of patients. This research is done by quantitative method. The design used was quasi-experimental using two groups pretest-postest design. Conducted on subjects totaling 20 people, meeting the inclusion criteria. Emotional Freedom Technique) therapy on decrease of depression level in diabetics mellitus patients at PKU Muhammadiyah Gamping Yogyakarta Hospital with p-value <0,05 through paired sample t test. Based on the results of the study, there was a significant effect between before and after SEFT (Spiritual Emotional Freedom Technique) therapy to decrease depression level in patients with diabetes mellitus in patients at PKU Muhammadiyah Gamping Hospital in Yogyakarta.