This research aims to influence of Investment, Labor, and Education on Economic Growth in the Special Region of Yogyakarta (DIY). This research uses Panel Data which is combination of 5 Districts/Cities in the period 2010 – 2015, with variables Investment, Labor, and Education Level in Special Region of Yogyakarta (DIY). The method used in this research is the regression panel that is in the process by using the random effects approach. The result of this research indicate that investment variables have a positive and significant impact on economic growth, labor has possitive and significant impact on economic growth, education level has a possitive and significant impact on economic growth.