The purpose of this research is to analyze the condition of Mendong handicrafts industrial centers in Purbaratu, Tasikmalaya with Quintuple Helix approach. The components on this research is Goverment, Academics, Enterpreneurs, Financial institutions and the Media. The data was obtained through intervies with informans that selected on the basis of purposive sampling. The analysis was done by reduction of data, presenting data and draw conclusions. The results showed that first, the role of Goverment as the creation of a program or policy is as creative industry development planning. Second, the role of Academics as a human resource capital which could bring innovations. Thrid, the role of Entrepeneurs as manager in the production of Mendong handicrafts. Fourth, the financial institution as capital financing. Fifth, the role of the Media asas information promotion. The condition of the industrial centers of Mendong handicrafts decreased because there were some problems, namely lack human resources or generation, market opportunities has not been maximized, lack of innovation and creativity that need the power of five the component to cooperate in achieving the SDGs. The fifth component in the Mendong handicraft industry have the role and influence of each other