Background: The incidence of obesity, generally still showing improvement and becoming a health problem worldwide, including Indonesia (Dullo, 2004). WHO officially declared obesity as a global epidemic (Caballero, 2007) .SOFIA (Smart Software for Weight Loss) created by UMY Doctor Education students in 2014, is a weight loss program that applies to smartphones, with some program components, such as hypnotics therapy, sports schedule reminders, daily consumption pattern reminders, and diet guideline. Aim: This study aims to determine the effect of the intervention of SOFIA and dietary Guideline on weight loss, and waist circumference.. Research method: This study used a Clinical experimental study with pre-post test control group design. The study group was divided into treatment group and control group was given the intervention of using SOFIA and Auastralian Dietary Guideline while control group was given intervention using Australian GuideLine diet only Result and discussion: The result of Paired Sample T-Test test in the treatment group obtained a significance value of p = 0.001 on the weight difference analysis and p = 0.67 in the analysis of Waist Circumference, which means that there is a significant influence on weight loss and insignificant change in waist circumference .The result of the control group test was obtained significance value of p = 0.378 on the analysis of weight difference and p = 0,204 oada Waist Circle, which means there is no significant change in the change of body weight and waist circumference. Analysis of Independent sample T-Tes different value ( Δ) Post test and pre-test difference between treatment and control group was found significance p = 0.003 on difference in body weight, and significance value of p = 0.20 on analisia difference in gap of waist circumference, which means there is a significant change in the decrease Weight gain and insignificant change in waist circumference between treatment and control group . Conclusion: The provision of Sofia and CPG Interventions had a significant effect on weight loss and insignificant effect on Waist circumference..