Background: Chronic Obstructive Pulmonary Disease (COPD) is the largest cause of morbidity and mortality in the world after cardiovascular and cerebrovascular diseases. World Health Organization estimates that COPD will increase to 7.9% in 2030. The highest prevalence of respiratory disturbances are smokers. The longer and the number of cigarettes consumed, the greater the risk of lung disease. The severity of airway obstruction affects the decline in the quality of life of patients with COPD. Objective: To determine the relationship of smoking status on quality of life in COPD patients with a questionnaire SGRQ. Methods: Design research used analytic method with sample number 96 in Yogyakarta Respira Pulmonary Hospital. The sampling was done randomly. To describe the quality of life, using the SGRQ questionnaire consists of three aspects, namely activity, symptomp, impact. It was said quality of life worse if > 50, and good quality of life if ≤ 50. Results: The results showed that the number of patients with active smokers were 6 (6.25%) ang the smokers (current smokers and formed smoked) were 46 (48%). The number of good quality of life in symptomp, activity, and impact aspects were 46 people (47.90%), 30 (31.20%), and 54 (56.20%). The number of poor quality of life in symptomps, activity, and impact aspects were 50 people (52.10%), 66 (68.80%), and 42 (43.80%). The number of patients with a good quality of life based on the total SGRQ score were 38 (39.60%) and poor quality of life were 58 (60.40%). Conclusions: There was not relationship of smoking status on quality of life in COPD patients with a questionnaire SGRQ.